Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8 (2024)

THC-O acetate is even stronger than regular THC. Here’s what you need to know to try it safely.

From delta-8 to delta-10, cannabinoids from hemp are having a moment. And now there’s a new kid on the block poised for a takeover: THC-O. But while the deltas are gentler versions of the classic THC, or delta-9 of cannabis fame, THC-O can be three times stronger than its more mainstream cousin.

Because it’s made from hemp, THC-O occupies a different legal status than cannabis products, especially in many states that don’t have a recreational market yet. That being said, there is still some debate about whether THC-O constitutes “synthetic THC” under federal law, which is still a controlled substance and illegal even when derived from hemp, so proceed with caution.

There’s still a lot we’re learning about THC-O, although there’s research on it dating back as far as the 1940s. As its popularity rises, it’s critical to keep up with the facts—and how to find safe, effective, reputable products.

RelatedMeet THC-O, a hemp-derived compound three times stronger than THC

Here’s what we know about THC-O and how you can make sure it’s coming from a trusted source before you give it a try.

Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8 (1)

What is THC-O and where does it come from?

THC-O’s full name is THC-O acetate, and the earliest research we have on it dates back to American military experiments on non-lethal incapacitating agents in the 1940s. Researchers tested the compound on dogs. At the end of the experiment, the dogs had lost significant control of their motor function.

To derive THC-O from hemp, first CBD is converted to delta-8 or a similar THC modification. But it goes one step further. By adding Acetic Anhydride to the mix, it becomes an acetate—specifically, THC-O.

RelatedWhat is delta-8?

But don’t try this at home! Acetic Anhydride is highly corrosive and flammable, and puts your health, safety, and environment at risk unless it’s made in a highly-controlled lab environment. This is one of several reasons why you should only buy THC-O if you know it came from a reputable source.

How do you take THC-O?

Once finished, THC-O acetate is a kind of thick brown liquid. You can take it in a vape cartridge, a tincture, or an edible. It takes about 20-30 minutes to kick in.

Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8 (2)

What does THC-O feel like? How is it different from delta-8, -9, and -10?

Delta-8 and delta-10 are both milder, and generally less intoxicating, than traditional delta-9 THC. Delta-8 is known for more sedative effects, while delta-10 has a reputation for a more active, sativa-like high.

THC-O is significantly stronger than not only delta-8 and -10, but also regular THC. Some consumers have reported a more spiritual high with strong effects that can even border on hallucinogenic. Like any drug, effects and tolerance are going to vary from person to person.

RelatedWhat is delta-10?

How to buy THC-O safely

With THC-O largely unregulated, there are a lot of risks to buying THC-O from a mystery source. Cannabis researcher James Stephens told Leafly that sometimes producers don’t even know, or claim to not know, what’s in their own product: “I ask, ‘What’s the rest of the stuff?’, and they say, ‘We don’t know’…That’s what usually shuts down the conversation.”

There’s a possibility of toxic additives in THC-O oil, too—and we’ve already seen sketchy additives cause serious health problems. Because it’s so much stronger than other forms of THC, you’ll especially want an accurate potency.

You’ll want to buy from a company that’s completely transparent, with clear lab results and a high level of accountability to its customers. five has been making trusted, transparent, full-spectrum products that combine CBD with other beneficial hemp compounds for years, and they were one of the first companies to offer products containing delta-9 and delta-10. They know how to create perfect mixes of cannabinoids—and they’re experienced at making them safely, with the consumer’s experience in mind. They even offer certificates of analysis from third-party labs so you know that what it says on the bottle matches what’s inside the product.

Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8 (3)

five has been hard at work developing THC-O products that meet their high standards. For now, you can get to know them through their fan-favorite offerings—and if THC-O appeals to you, you’ll know that you have a producer that you can trust for a great experience.

Right now, five is offering a special deal for Leafly readers. Hit the link below to try a full size product for free. You just pay shipping, and five covers the rest.

Daily Buzz Gummies: five’s flagship gummies are both delicious and powerful, with a full suite of beneficial plant compounds and 5mg delta-9 THC per gummy. Like all their gummies, they’re vegan, too. *Availability subject to local laws.

Sleep Gummies: five’s gummies for better rest add natural sleep aid melatonin to their perfect blend of hemp-derived cannabinoids—with up to six times the minor cannabinoids as other brands.

THC+CBD Liquid Capsules: Get all the benefits of full-spectrum hemp in an easy-to-use capsule packed with CBD, THC, CBN, and CBC.

Full Spectrum THC+CBD Chocolate: For a more luxurious edible experience, five offers their signature blend of cannabinoids in two flavors of chocolate: Milk Chocolate and Sea Salt Dark Chocolate.

Full Spectrum THC+CBD Oil: This is the oil that started it all. Two flavors of tinctures, citrus and mint chocolate, are packed with CBD, THC, CBN, CBC, and terpenes.

Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8 (4)
Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8 (2024)

FAQs

Comparing THC compounds: What we know about THC-O versus delta-9 & delta-8? ›

Delta-8 and delta-10 are both milder, and generally less intoxicating, than traditional delta-9 THC. Delta-8 is known for more sedative effects, while delta-10 has a reputation for a more active, sativa-like high. THC-O is significantly stronger than not only delta-8 and -10, but also regular THC.

What is the difference between delta-9 and delta-9 THC-O? ›

THC-O and delta-9 both provide a potent high, however, most people find that THC-O is roughly three to four times stronger than delta-9. Like delta-9, THC-O provides the signature euphoric high effects. Unlike delta-9, THC-O may induce psychedelic effects.

Why was THC-O banned? ›

Why did the DEA determine that THC-O is illegal under the Farm Bill? Simply put, THC-O is a controlled substance because it is not naturally occurring and not derived from the hemp plant.

What is the difference between Delta 8 THC and THC-O? ›

Delta 8 THC and THC-O have key differences and similarities. Delta 8 is less potent, offering a milder high and is naturally in the hemp plant. It's known for relaxation and potential therapeutic benefits. THC-O, a synthetic version of THC, is much more potent with stronger body and mind effects.

What is the strongest THC derivative? ›

THC-P: The Strongest THC Variant

THC-P is derived from the hemp plant and also extracted similarly to Delta-8 THC, but it's wildly potent. THC-P is 30x stronger than Delta-9 THC, but some research indicates that it's actually 33x stronger. This truly makes it the most psychoactive cannabinoid.

What is the strongest form of delta? ›

Delta-3 and Delta-6: The potency of these two is not conclusively known. However, it's speculated they might have potencies similar to or in between delta-8 and 9. Delta-9: Traditionally recognized as the primary psychoactive compound in cannabis, delta-9 THC stands out as the most potent among the deltas listed.

Is delta-9 synthetic or natural? ›

Naturally-occurring delta-9 is different from the synthetic product called delta-9 THC-O acetate, which is an oily brown residue sold as a vaping product or used in gummies. Research is limited on the strength and risks of this chemical.

Why is THC-O illegal in Texas? ›

Created with the addition of acetate to a delta-8 or delta-9 compound, THC-O is reported to be more potent than other cannabinoids. As of 2023, the U.S. Drug Enforcement Administration considers THC-O illegal because it is not naturally occurring and thus is not covered by the Farm Bill.

Why is Delta 10 illegal? ›

Is Delta-10 a Controlled Substance in California? No, Delta-10 is not a Controller Substance in California. The only regulation here is that the product in question much contain less than 0.3% THC on a dry-weight basis. Keep in mind that some states are cracking down on alt and minor cannabinoids.

Is THC-O legal in all 50 states? ›

It has been decriminalized in Minnesota, North Dakota, Missouri, New Hampshire, and Alabama as well. The states where THC-O is illegal include Alaska, Arizona, Arkansas, Colorado, Delaware, Idaho, Iowa, Mississippi, Montana, New York, Rhode Island, Utah, and Vermont.

What THC is stronger than Delta 8? ›

It is thought that delta-10 THC has greater potency than delta-8 THC. The cannabinoid's increased ability to affect the cannabinoid receptors produces a stronger psychoactive effect. However, a person's tolerance and the mode of consumption can both affect how potent delta-8 THC is.

Is Delta 11 better than THC-O? ›

While delta-11 THC offers a more relaxing effect, THC-O offers an uplifting high that can be felt at a much higher level. Furthermore, THC-O can provide users with medicinal effects that are not found in delta-11 THC. As such, those looking for a more potent, head-focused high should consider THC-O as a viable option.

What is the difference between THC-O and THC 8? ›

Delta-8 THC is non-acidic, while THCa is an acidic version of THC. Another difference is the effects the two deliver. THCa does not have psychoactive effects and will not make you feel uplifted or hazy, while Delta-8 does have noticeable psychoactive effects, though not as strong as Delta-9.

What is the strongest THC in the world? ›

Godfather OG:

THC Percentage: Godfather OG is renowned for its high THC content, often exceeding 34%.

What's the strongest form of THC? ›

This cannabinoid is difficult to extract and accumulate, making the manufacture of THCP products difficult and expensive. The strongest accessible form of THC is delta-9. This cannabinoid is found in higher concentrations, is easier to extract, is less expensive, and has a decreased risk of side effects.

Which delta-9 is the strongest? ›

The strongest legal delta-9 THC gummies on the market are the UFO Max gummies from Area 52. The gummies contain 15 mg of hemp-derived THC, 100 mg of CBD, and 5 mg of CBG. These levels are unrivaled in the legal THC edible space. The team has achieved this otherworldly potency by increasing the weight of the gummies.

How much THC-O should I take? ›

As a moderately experienced weed user, one-quarter of a standard THC-O gummy, which equates to 6.25mg, should be the maximum you use. As an experienced marijuana user, half a gummy is the most you should try at first, as this offers 12.5mg of THC-O.

How much delta-9 gets you high? ›

High Dose. A high dose is from 25 to 50 milligrams of Delta-9 THC. This dose is for seasoned edible eaters and is perfect for people who know what to expect. At this point, you'll definitely feel heavy effects of euphoria, couch-lock and will definitely be stoned.

Is delta-9 indica or sativa? ›

Key Takeaways. Delta 9 THC can be found in both indica and sativa strains. The sativa and indica ratio depends on the strain of the cannabis used in the production of the delta 9 products. Most people prefer hybrid delta 9 products with a unique blend of indica and sativa.

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